Small molecules which reverse FGFR2 activemutant
Canned Analysis
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General Information
AccessionDCA00021300
TitleSmall molecules which reverse FGFR2 activemutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by FGFR2 activemutant in the MMTV-Wnt-1 transgenic mice cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d229fae467bea600fbb3c2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1895
Cell TypeMMTV-Wnt-1 transgenic mice
Gene Symbol (human)FGFR2
Gene Symbol (mouse)Fgfr2
Organismmouse
Perturbation Typeactivemutant
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM447004, GSM447559, GSM447560, GSM447561, GSM447562, GSM447563
Perturbed SamplesGSM447568, GSM447569, GSM447570, GSM447571
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE17916
Gene Expression Omnibus
FGF Receptor and Wnt-1 Signaling Cooperate in Mammary Tumorigenesis
14
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