Small molecules which mimic JAK2 activemutant
Canned Analysis
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General Information
AccessionDCA00021315
TitleSmall molecules which mimic JAK2 activemutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by JAK2 activemutant in the LSK cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fa82e467bea600fb9f12
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1901
Cell TypeLSK cells
Gene Symbol (human)JAK2
Gene Symbol (mouse)Jak2
Organismmouse
Perturbation Typeactivemutant
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM543489, GSM543490, GSM543491, GSM543492
Perturbed SamplesGSM543493, GSM543494, GSM543495, GSM543496
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE21842
Gene Expression Omnibus
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
7
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