Small molecules which reverse ABL1 druginhibition
Canned Analysis
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General Information
AccessionDCA00021322
TitleSmall molecules which reverse ABL1 druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ABL1 druginhibition in the chronic myelogenous leukemia cell lines KU-812, KCL-22 and JURL-MK1 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fa57e467bea600fb9f00
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1904
Cell Typechronic myelogenous leukemia cell lines KU-812, KCL-22 and JURL-MK1
Gene Symbol (human)ABL1
Gene Symbol (mouse)Abl1
Organismhuman
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM603097, GSM603099, GSM603101
Perturbed SamplesGSM603098, GSM603100, GSM603102
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE24493
Gene Expression Omnibus
Imatinib treatment of chronic myeloid leukemia cell lines: KU-812, KCL-22 and JURL-MK1
12
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