Small molecules which reverse JAK2 knockout
Canned Analysis
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General Information
AccessionDCA00021326
TitleSmall molecules which reverse JAK2 knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by JAK2 knockout in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fa69e467bea600fb9f08
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1906
Cell Typeliver
Gene Symbol (human)JAK2
Gene Symbol (mouse)Jak2
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM642852, GSM642853, GSM642854, GSM642858, GSM642859, GSM642860
Perturbed SamplesGSM642855, GSM642856, GSM642857, GSM642861, GSM642862, GSM642863
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26188
Gene Expression Omnibus
Liver gene expression in animals with hepatocyte-specific deletion of JAK2
7
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