Small molecules which reverse PDK1 knockout
Canned Analysis
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General Information
AccessionDCA00021328
TitleSmall molecules which reverse PDK1 knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PDK1 knockout in the cytotoxic T-lymphocytes cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fa72e467bea600fb9f0c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1907
Cell Typecytotoxic T-lymphocytes
Gene Symbol (human)PDK1
Gene Symbol (mouse)Pdk1
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM645610, GSM645612, GSM645614
Perturbed SamplesGSM645607, GSM645608, GSM645609
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE26290
Gene Expression Omnibus
Expression data from control and Phospholipid dependent kinase 1 (PDK1) null cytotoxic T-lymphocytes (CTL) and from control and Akt inhibitor treated ...
14
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