Small molecules which reverse AKT1 druginhibition
Canned Analysis
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General Information
AccessionDCA00021330
TitleSmall molecules which reverse AKT1 druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by AKT1 druginhibition in the cytotoxic T-lymphocytes cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1faace467bea600fb9f24
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1908
Cell Typecytotoxic T-lymphocytes
Gene Symbol (human)AKT1
Gene Symbol (mouse)Akt1
Organismmouse
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM645610, GSM645612, GSM645614
Perturbed SamplesGSM645611, GSM645613, GSM645615
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE26290
Gene Expression Omnibus
Expression data from control and Phospholipid dependent kinase 1 (PDK1) null cytotoxic T-lymphocytes (CTL) and from control and Akt inhibitor treated ...
14
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