Small molecules which mimic EGFR druginhibition
Canned Analysis
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General Information
AccessionDCA00021331
TitleSmall molecules which mimic EGFR druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by EGFR druginhibition in the hepatocellular carcinoma cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fab3e467bea600fb9f26
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1909
Cell Typehepatocellular carcinoma
Gene Symbol (human)EGFR
Gene Symbol (mouse)Egfr
Organismrat
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM684868, GSM684869, GSM684870
Perturbed SamplesGSM684865, GSM684866, GSM684867
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE27638
Gene Expression Omnibus
Gene expression profile of hepatocellular carcinoma in low-dose, repeated diethylnitrosamine (DEN)-treated rat treated with erlotinib
7
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