Small molecules which reverse MAP3K1 OE
Canned Analysis
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General Information
AccessionDCA00021336
TitleSmall molecules which reverse MAP3K1 OE
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MAP3K1 OE in the Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fe8ee467bea600fba0d8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:192
Cell TypeEstrogen receptor (ER) alpha positive MCF-7 breast cancer cells
Gene Symbol (human)MAP3K1
Gene Symbol (mouse)Map3k1
Organismhuman
Perturbation TypeOE
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM81189, GSM81190, GSM81191
Perturbed SamplesGSM81198, GSM81199, GSM81200
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE3542
Gene Expression Omnibus
Estrogen receptor alpha positive breast cancer cells response to hyperactivation of MAPK pathway
28
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