Small molecules which reverse EGFR druginhibition
Canned Analysis
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General Information
AccessionDCA00021342
TitleSmall molecules which reverse EGFR druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by EGFR druginhibition in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f534e467bea600fb9cfc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1910
Cell Typeliver
Gene Symbol (human)EGFR
Gene Symbol (mouse)Egfr
Organismmouse
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM684879, GSM684880, GSM684881, GSM684882
Perturbed SamplesGSM684883, GSM684884, GSM684885, GSM684886
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE27640
Gene Expression Omnibus
Gene expression profile of liver tissue in carbon tetrachloride (CCl4)-treated mouse treated with erlotinib
7
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