Small molecules which reverse ITK defectivemutant
Canned Analysis
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General Information
AccessionDCA00021344
TitleSmall molecules which reverse ITK defectivemutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ITK defectivemutant in the HVS transformed CD4+ T cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f52be467bea600fb9cf8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1911
Cell TypeHVS transformed CD4+ T cells
Gene Symbol (human)ITK
Gene Symbol (mouse)Itk
Organismhuman
Perturbation Typedefectivemutant
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM698337, GSM698338, GSM698339
Perturbed SamplesGSM698340, GSM698341, GSM698342
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE28200
Gene Expression Omnibus
Expression data of ITK deficient, HVS transformed CD4+ T cells
7
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