Small molecules which reverse SYK druginhibition
Canned Analysis
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General Information
AccessionDCA00021362
TitleSmall molecules which reverse SYK druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by SYK druginhibition in the DHL6 or DHL4 diffuse large b-cell lymphoma cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23931e467bea600fbba76
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1933
Cell TypeDHL6 or DHL4 diffuse large b-cell lymphoma cell line
Gene Symbol (human)SYK
Gene Symbol (mouse)Syk
Organismhuman
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM843447, GSM843448, GSM843449, GSM843450, GSM843451
Perturbed SamplesGSM843470, GSM843471, GSM843472, GSM843473, GSM843474, GSM843475
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE34176
Gene Expression Omnibus
Spleen tyrosine kinase inhibitor effect on diffuse large B-cell lymphoma cell lines: time course
28
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