Small molecules which reverse MAP2K1 druginhibition
Canned Analysis
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General Information
AccessionDCA00021378
TitleSmall molecules which reverse MAP2K1 druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MAP2K1 druginhibition in the mouse melanoma model cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d233abe467bea600fbb804
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1944
Cell Typemouse melanoma model
Gene Symbol (human)MAP2K1
Gene Symbol (mouse)Map2k1
Organismmouse
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM982953, GSM982954, GSM982955, GSM982956, GSM982957, GSM982958
Perturbed SamplesGSM982965, GSM982966, GSM982967, GSM982968, GSM982969, GSM982970
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE39984
Gene Expression Omnibus
Comparison of the genetic extinction of NRAS to pharmacological MEK inhibition in an inducible mouse model of melanoma
7
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