Small molecules which reverse ABL1 mutant
Canned Analysis
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General Information
AccessionDCA00021384
TitleSmall molecules which reverse ABL1 mutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ABL1 mutant in the cord blood cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22e56e467bea600fbb5ae
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1950
Cell Typecord blood cells
Gene Symbol (human)ABL1
Gene Symbol (mouse)Abl1
Organismhuman
Perturbation Typemutant
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1104493, GSM1104494, GSM1104495, GSM1104496
Perturbed SamplesGSM1104497, GSM1104498, GSM1104499, GSM1104500
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE45452
Gene Expression Omnibus
BCR-ABL1 and a dominant negative isoform of Ikaros cooperate to induce human acute myeloid leukemia
7
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