Small molecules which reverse CDK9 druginhibition
Canned Analysis
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General Information
AccessionDCA00021388
TitleSmall molecules which reverse CDK9 druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CDK9 druginhibition in the CLL cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22e45e467bea600fbb5a6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1953
Cell TypeCLL
Gene Symbol (human)CDK9
Gene Symbol (mouse)Cdk9
Organismhuman
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1173423, GSM1173424, GSM1173425
Perturbed SamplesGSM1173426, GSM1173427, GSM1173428
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48258
Gene Expression Omnibus
Changes in gene expression induced by CDK9 inhibition alone and in combination with fludarabine
7
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