Small molecules which reverse MELK druginhibition
Canned Analysis
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General Information
AccessionDCA00021396
TitleSmall molecules which reverse MELK druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MELK druginhibition in the glioma stem cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22e32e467bea600fbb59e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1956
Cell Typeglioma stem cells
Gene Symbol (human)MELK
Gene Symbol (mouse)Melk
Organismhuman
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1216108, GSM1216110, GSM1216112
Perturbed SamplesGSM1216109, GSM1216111, GSM1216113
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE50227
Gene Expression Omnibus
Glioma stem cell treatment with MELK-signaling inhibitors
7
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