Small molecules which mimic SYK knockdown
Canned Analysis
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General Information
AccessionDCA00021401
TitleSmall molecules which mimic SYK knockdown
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by SYK knockdown in the U937 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22e5de467bea600fbb5b0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1959
Cell TypeU937
Gene Symbol (human)SYK
Gene Symbol (mouse)Syk
Organismhuman
Perturbation Typeknockdown
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1306638, GSM1306639, GSM1306640
Perturbed SamplesGSM1306641, GSM1306642, GSM1306643, GSM1306644
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54065
Gene Expression Omnibus
SYK Is a Critical Regulator of FLT3 In Acute Myeloid Leukemia
21
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