Small molecules which mimic AURKA druginhibition
Canned Analysis
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General Information
AccessionDCA00021417
TitleSmall molecules which mimic AURKA druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by AURKA druginhibition in the mNB-A1 neuroblastoma cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22922e467bea600fbb360
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1964
Cell TypemNB-A1 neuroblastoma cell line
Gene Symbol (human)AURKA
Gene Symbol (mouse)Aurka
Organismmouse
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1390726, GSM1390727, GSM1390728, GSM1390729, GSM1390730, GSM1390731
Perturbed SamplesGSM1390735, GSM1390736, GSM1390737
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE57810
Gene Expression Omnibus
Expression profiling of tumor cells from MYCN-driven neuroblastoma upon BRD4 or AURKA inhibition
7
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