Small molecules which mimic AKT1 knockout
Canned Analysis
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General Information
AccessionDCA00021429
TitleSmall molecules which mimic AKT1 knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by AKT1 knockout in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22450e467bea600fbb13c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1979
Cell Typeliver
Gene Symbol (human)AKT1
Gene Symbol (mouse)Akt1
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM977891, GSM977892, GSM977893, GSM977894
Perturbed SamplesGSM977895, GSM977896, GSM977897, GSM977898
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39699
Gene Expression Omnibus
gene expression signatures of Akt1 +/- mice at 8weeks and 35weeks
35
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