Small molecules which reverse AKT2 knockout
Canned Analysis
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General Information
AccessionDCA00021442
TitleSmall molecules which reverse AKT2 knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by AKT2 knockout in the heart cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21ee1e467bea600fbaede
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1983
Cell Typeheart
Gene Symbol (human)AKT2
Gene Symbol (mouse)Akt2
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM472351, GSM472352, GSM472353
Perturbed SamplesGSM472350, GSM472354, GSM472355
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE19079
Gene Expression Omnibus
Myocardial expression data from wild-type and akt2-/- mice
7
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