Small molecules which mimic CDK4 knockdown
Canned Analysis
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General Information
AccessionDCA00021447
TitleSmall molecules which mimic CDK4 knockdown
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by CDK4 knockdown in the IMR-32 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d21eb8e467bea600fbaecc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1987
Cell TypeIMR-32
Gene Symbol (human)CDK4
Gene Symbol (mouse)Cdk4
Organismhuman
Perturbation Typeknockdown
None{u'vals': [0.0402710304397, 0.0388046266098, 0.0372196339108, 0.0371656527783, -0.0364691794925, 0.0360509234586, 0.0355038835249, 0.0348491400967, 0.0342044513455, 0.0326396519607, 0.0325756125895, 0.0317195103794, -0.0314642399633, -0.0313235995535, 0.0
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM220189, GSM220205, GSM220208
Perturbed SamplesGSM220191, GSM220207, GSM220210
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8866
Gene Expression Omnibus
The undifferentiated phenotype in neuroblastoma depends on Cyclin D1 and CDK4 activity
14
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