Small molecules which reverse CCND1 KD
Canned Analysis
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General Information
AccessionDCA00021450
TitleSmall molecules which reverse CCND1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CCND1 KD in the imr_neuroblastoma cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23d5fe467bea600fbbc4c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorKevin
CREEDS IDgene:2163
Cell Typeimr_neuroblastoma
Gene Symbol (human)CCND1
Gene Symbol (mouse)Ccnd1
Organismhuman
Perturbation TypeKD
None{u'vals': [0.0463062626345, -0.0385926826376, 0.0375535798408, 0.0364598641833, 0.035367676846, -0.0335003347734, 0.033296895801, 0.0331131880597, 0.0330782579577, -0.0325306463576, 0.0323416325606, -0.031944868176, 0.0319335675348, -0.0314599866862, 0.03
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM220186, GSM220199, GSM220203
Perturbed SamplesGSM220188, GSM220206, GSM220209
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8866
Gene Expression Omnibus
The undifferentiated phenotype in neuroblastoma depends on Cyclin D1 and CDK4 activity
14
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