Small molecules which reverse MET knockout
Canned Analysis
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General Information
AccessionDCA00021460
TitleSmall molecules which reverse MET knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MET knockout in the primary hepatocytes, HGF stimulation cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1f2e8e467bea600fb9c00
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2000
Cell Typeprimary hepatocytes, HGF stimulation
Gene Symbol (human)MET
Gene Symbol (mouse)Met
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM100094, GSM100095, GSM100096, GSM100097, GSM100098, GSM100099
Perturbed SamplesGSM100088, GSM100089, GSM100090, GSM100091, GSM100092, GSM100093
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE4451
Gene Expression Omnibus
Hepatocyte growth factor effect on Met receptor-knockout primary hepatocytes: time course
35
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