Small molecules which reverse TGFBR2 knockout
Canned Analysis
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General Information
AccessionDCA00021498
TitleSmall molecules which reverse TGFBR2 knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TGFBR2 knockout in the aorta cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d236c5e467bea600fbb964
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2025
Cell Typeaorta
Gene Symbol (human)TGFBR2
Gene Symbol (mouse)Tgfbr2
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM900960, GSM900961, GSM900962
Perturbed SamplesGSM900963, GSM900964, GSM900965
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36778
Gene Expression Omnibus
Effect of Tgfbr2 disruption on gene expression in the aorta of Fbn1 wild-type and Fbn1C1039G mice
7
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