Small molecules which reverse TRIM28 knockout
Canned Analysis
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General Information
AccessionDCA00021514
TitleSmall molecules which reverse TRIM28 knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by TRIM28 knockout in the CD4+ T cell cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d23168e467bea600fbb706
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2033
Cell TypeCD4+ T cell
Gene Symbol (human)TRIM28
Gene Symbol (mouse)Trim28
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM798457, GSM798458, GSM798459, GSM798460
Perturbed SamplesGSM798465, GSM798466, GSM798467, GSM798468
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE32224
Gene Expression Omnibus
Comparison of gene expression in Wild type and T cell-specific conditional Trim28 KO in TCR stimulated and un-stimulated naive CD4 positive and T regu...
21
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