Small molecules which mimic PIK3CA activemutant
Canned Analysis
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General Information
AccessionDCA00021527
TitleSmall molecules which mimic PIK3CA activemutant
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PIK3CA activemutant in the MCF10A cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22ceee467bea600fbb510
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2042
Cell TypeMCF10A
Gene Symbol (human)PIK3CA
Gene Symbol (mouse)Pik3ca
Organismhuman
Perturbation Typeactivemutant
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM443978, GSM443979, GSM443980
Perturbed SamplesGSM443984, GSM443985, GSM443986
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE17785
Gene Expression Omnibus
Endogenous expression of an oncogenic PI3K mutation leads to activated PI3K pathway signaling and an invasive phenotype
7
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