Small molecules which mimic PIK3CA knockdown
Canned Analysis
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General Information
AccessionDCA00021553
TitleSmall molecules which mimic PIK3CA knockdown
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PIK3CA knockdown in the lung cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d227e7e467bea600fbb2d4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2052
Cell Typelung cancer cells
Gene Symbol (human)PIK3CA
Gene Symbol (mouse)Pik3ca
Organismmouse
Perturbation Typeknockdown
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1139464, GSM1139465, GSM1139466
Perturbed SamplesGSM1139467, GSM1139468, GSM1139469
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE46869
Gene Expression Omnibus
Gene expression profiles of PIK3CA knockdown by shRNA in lung cancer cells
7
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