Small molecules which reverse ERBB3 knockout
Canned Analysis
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General Information
AccessionDCA00021558
TitleSmall molecules which reverse ERBB3 knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ERBB3 knockout in the mammary organoids cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d227d9e467bea600fbb2ce
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2056
Cell Typemammary organoids
Gene Symbol (human)ERBB3
Gene Symbol (mouse)Erbb3
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM796433, GSM796434, GSM796435
Perturbed SamplesGSM796436, GSM796437, GSM796438
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE32129
Gene Expression Omnibus
Targeted ErbB3 loss in mammary organoids harvested from ErbB3 DOX-KO mice +/- DOX treatment
7
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