Small molecules which reverse PRKACA knockout
Canned Analysis
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General Information
AccessionDCA00021562
TitleSmall molecules which reverse PRKACA knockout
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PRKACA knockout in the caudal vertebral bone cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20386e467bea600fba30a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2058
Cell Typecaudal vertebral bone
Gene Symbol (human)PRKACA
Gene Symbol (mouse)Prkaca
Organismmouse
Perturbation Typeknockout
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM524645, GSM524646, GSM524647, GSM524648
Perturbed SamplesGSM524649, GSM524650, GSM524651, GSM524652
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20984
Gene Expression Omnibus
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone
7
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