Small molecules which mimic WEE1 druginhibition
Canned Analysis
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General Information
AccessionDCA00021565
TitleSmall molecules which mimic WEE1 druginhibition
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by WEE1 druginhibition in the PC3 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22271e467bea600fbb06c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2064
Cell TypePC3
Gene Symbol (human)WEE1
Gene Symbol (mouse)Wee1
Organismhuman
Perturbation Typedruginhibition
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM953063, GSM953067, GSM953071
Perturbed SamplesGSM953064, GSM953068, GSM953072
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE38972
Gene Expression Omnibus
Wee1 Inhibition sensitizes prostate cancer cells to Hsp90 inhibitor to activate the intrinsic apoptotic pathway
7
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