Small molecules which reverse JAK2 knockdown
Canned Analysis
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General Information
AccessionDCA00021568
TitleSmall molecules which reverse JAK2 knockdown
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by JAK2 knockdown in the HEL cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2226be467bea600fbb06a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2067
Cell TypeHEL
Gene Symbol (human)JAK2
Gene Symbol (mouse)Jak2
Organismhuman
Perturbation Typeknockdown
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1320628, GSM1320629, GSM1320630, GSM1320637, GSM1320638, GSM1320639
Perturbed SamplesGSM1320631, GSM1320632, GSM1320633, GSM1320634, GSM1320635, GSM1320636
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54645
Gene Expression Omnibus
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]
7
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