Small molecules which mimic HSF1 KD
Canned Analysis
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General Information
AccessionDCA00021607
TitleSmall molecules which mimic HSF1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by HSF1 KD in the RKO_colon_carcinoma cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2329ee467bea600fbb78c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorKevin
CREEDS IDgene:2142
Cell TypeRKO_colon_carcinoma
Gene Symbol (human)HSF1
Gene Symbol (mouse)Hsf1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM320083, GSM320084, GSM320085
Perturbed SamplesGSM320165, GSM320166, GSM320167
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE12762
Gene Expression Omnibus
Effect of 4-Hydroxynonenal on gene expression. Comparison of HSF1-siRNA silenced vs control cells
7
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