Small molecules which reverse NFE2L2 KO
Canned Analysis
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General Information
AccessionDCA00021622
TitleSmall molecules which reverse NFE2L2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by NFE2L2 KO in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d237fbe467bea600fbb9ec
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorKevin
CREEDS IDgene:2151
Cell Typeliver
Gene Symbol (human)NFE2L2
Gene Symbol (mouse)Nfe2l2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM862310, GSM862311, GSM862312
Perturbed SamplesGSM862313, GSM862314, GSM862315
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE35124
Gene Expression Omnibus
Comparison of gene expression profiles among Nrf1 liver-specific conditional knockout, Nrf2 knockout and Keap1 knockdown mice.
14
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