Small molecules which mimic AKT1 KO
Canned Analysis
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General Information
AccessionDCA00021681
TitleSmall molecules which mimic AKT1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by AKT1 KO in the Embryonic fibroblasts (MEFs) - 48h cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d209b7e467bea600fba5c0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:224
Cell TypeEmbryonic fibroblasts (MEFs) - 48h
Gene Symbol (human)AKT1
Gene Symbol (mouse)Akt1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM60211, GSM60212, GSM60229, GSM60230
Perturbed SamplesGSM60221, GSM60222, GSM60237, GSM60238
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE2746
Gene Expression Omnibus
Protein kinase B alpha knockout effect on adipogenesis: time course
35
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