Small molecules which reverse CCND1 KD
Canned Analysis
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General Information
AccessionDCA00021688
TitleSmall molecules which reverse CCND1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CCND1 KD in the MCF7 cells were transfected with control or cyclin D1 siRNA. Cells were maintained for 48hrs to allow for efficient knock-down. Vehicle treated cells were maintained for a further 24 hrs and then processed. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2232ce467bea600fbb0be
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2202
Cell TypeMCF7 cells were transfected with control or cyclin D1 siRNA. Cells were maintained for 48hrs to allow for efficient knock-down. Vehicle treated cells were maintained for a further 24 hrs and then processed.
Gene Symbol (human)CCND1
Gene Symbol (mouse)Ccnd1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1191286, GSM1191287
Perturbed SamplesGSM1191290, GSM1191291
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE48989
Gene Expression Omnibus
Cyclin D1 determines estrogen dependent signaling in human breast cancer cell line MCF7
14
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