Small molecules which mimic CCND1 KD
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00021689
TitleSmall molecules which mimic CCND1 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by CCND1 KD in the MCF7 cells were transfected with control or cyclin D1 siRNA. Cells were maintained for 48hrs to allow for efficient knock-down. Estradiol treated cells were maintained for a further 24 hrs and then processed. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2230de467bea600fbb0b0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2207
Cell TypeMCF7 cells were transfected with control or cyclin D1 siRNA. Cells were maintained for 48hrs to allow for efficient knock-down. Estradiol treated cells were maintained for a further 24 hrs and then processed.
Gene Symbol (human)CCND1
Gene Symbol (mouse)Ccnd1
Organismhuman
Perturbation TypeKD
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1191288, GSM1191289
Perturbed SamplesGSM1191292, GSM1191293
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48989
Gene Expression Omnibus
Cyclin D1 determines estrogen dependent signaling in human breast cancer cell line MCF7
14
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.