Small molecules which reverse LMNA HGPS single-point mutation
Canned Analysis
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General Information
AccessionDCA00021788
TitleSmall molecules which reverse LMNA HGPS single-point mutation
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by LMNA HGPS single-point mutation in the fibroblasts (bj-fib_2 and HGPS-fib_2) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22aefe467bea600fbb42e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2257
Cell Typefibroblasts (bj-fib_2 and HGPS-fib_2)
Gene Symbol (human)LMNA
Gene Symbol (mouse)Lmna
Organismhuman
Perturbation TypeHGPS single-point mutation
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM603015, GSM603043
Perturbed SamplesGSM603044, GSM603045
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24487
Gene Expression Omnibus
Induced pluripotent stem cell-based accelerated aging model
14
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