Small molecules which reverse PINK1 KO
Canned Analysis
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General Information
AccessionDCA00021800
TitleSmall molecules which reverse PINK1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by PINK1 KO in the Striatum- 24 weeks cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d216dee467bea600fbab8a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2265
Cell TypeStriatum- 24 weeks
Gene Symbol (human)PINK1
Gene Symbol (mouse)Pink1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1479270, GSM1479271, GSM1479272
Perturbed SamplesGSM1479267, GSM1479268, GSM1479269
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE60413
Gene Expression Omnibus
Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
105
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