Small molecules which mimic PINK1 KO
Canned Analysis
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General Information
AccessionDCA00021803
TitleSmall molecules which mimic PINK1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PINK1 KO in the Midbrain - 6 weeks cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d216eee467bea600fbab90
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2267
Cell TypeMidbrain - 6 weeks
Gene Symbol (human)PINK1
Gene Symbol (mouse)Pink1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1479241, GSM1479242, GSM1479243
Perturbed SamplesGSM1479238, GSM1479239, GSM1479240
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE60413
Gene Expression Omnibus
Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
105
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