Small molecules which reverse EGR2 KD
Canned Analysis
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General Information
AccessionDCA00021850
TitleSmall molecules which reverse EGR2 KD
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by EGR2 KD in the OT-I T cells from tumors cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d234d9e467bea600fbb88c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAliDot
CREEDS IDgene:2292
Cell TypeOT-I T cells from tumors
Gene Symbol (human)EGR2
Gene Symbol (mouse)Egr2
Organismmouse
Perturbation TypeKD
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1290692, GSM1290693, GSM1290694
Perturbed SamplesGSM1290698, GSM1290699, GSM1290700
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE53388
Gene Expression Omnibus
Tumor-infiltrating CD8 T cells silenced for negative regulators of T cells
70
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