Small molecules which reverse MN1 OE
Canned Analysis
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General Information
AccessionDCA00021874
TitleSmall molecules which reverse MN1 OE
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MN1 OE in the 72 hours after transduction with MSCV-IRES-GFP, gfp positive bone marrow cells were sorted and RNA isolated from FVB 129 mice cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d228ede467bea600fbb34a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2305
Cell Type72 hours after transduction with MSCV-IRES-GFP, gfp positive bone marrow cells were sorted and RNA isolated from FVB 129 mice
Gene Symbol (human)MN1
Gene Symbol (mouse)Mn1
Organismmouse
Perturbation TypeOE
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM333160, GSM333161, GSM333162
Perturbed SamplesGSM333157, GSM333158, GSM333159
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE13189
Gene Expression Omnibus
Functional collaboration of the meningioma 1 (MN1) oncogene with MLL-fusions in pediatric leukemia
7
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