Small molecules which reverse MYRF KO
Canned Analysis
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General Information
AccessionDCA00021876
TitleSmall molecules which reverse MYRF KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by MYRF KO in the cell: Cultured oligodendrocytes genotype: Myelin-gene Regulatory Factor conditional knockout (MRF fl/fl, Olig2 wt/cre) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d228e4e467bea600fbb346
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2306
Cell Typecell: Cultured oligodendrocytes genotype: Myelin-gene Regulatory Factor conditional knockout (MRF fl/fl, Olig2 wt/cre)
Gene Symbol (human)MYRF
Gene Symbol (mouse)Myrf
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM387042, GSM387043, GSM387044, GSM387045
Perturbed SamplesGSM387039, GSM387040, GSM387041
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE15303
Gene Expression Omnibus
Identification of Myelin-gene Regulatory Factor as a Critical Transcriptional Regulator Required for CNS Myelination
7
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