Small molecules which mimic KLF5 KO
Canned Analysis
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General Information
AccessionDCA00021887
TitleSmall molecules which mimic KLF5 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by KLF5 KO in the dorsal prostate, PTEN-null background cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22e09e467bea600fbb58c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:2318
Cell Typedorsal prostate, PTEN-null background
Gene Symbol (human)KLF5
Gene Symbol (mouse)Klf5
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1418653, GSM1418654, GSM1418655, GSM1418656
Perturbed SamplesGSM1418657, GSM1418658, GSM1418659, GSM1418660
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE58719
Gene Expression Omnibus
Expression data from conditional Klf5 knockout Pten-null mouse prostates
7
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