Small molecules which reverse HTRA2 KO
Canned Analysis
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General Information
AccessionDCA00021964
TitleSmall molecules which reverse HTRA2 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by HTRA2 KO in the cortex cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1fc89e467bea600fb9ff4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDgene:2361
Cell Typecortex
Gene Symbol (human)HTRA2
Gene Symbol (mouse)Htra2
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM326524, GSM326525, GSM326526
Perturbed SamplesGSM326527, GSM326528, GSM326529
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE13033
Gene Expression Omnibus
Differentially expressed genes in brain tissue from HtrA2 knockout mice
7
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