Small molecules which reverse ZBTB7A KO
Canned Analysis
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General Information
AccessionDCA00021998
TitleSmall molecules which reverse ZBTB7A KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by ZBTB7A KO in the strain/background: C57BL/6 genotype/variation: Zbtb7a Flox/Flox Mx1-Cre+ (LRF homozygous knockout) age: 4 weeks cell type: FACS-sorted LT-HSCs (LSK IL7Ra-Flt3-CD150+CD48-) time point: 9 days after 1st pIpC injection Treatment protocol LT-HSCs were FACS-sorted from three Lrf knockout (Zbtb7a Flox/Flox Mx1-Cre+) and two control (Zbtb7a Flox/+ Mx1-Cre+) mice, nine days after the first pIpC injection. pIpC (250μg) was injected twice to induce Cre recombinase. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d22644e467bea600fbb21a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2380
Cell Typestrain/background: C57BL/6 genotype/variation: Zbtb7a Flox/Flox Mx1-Cre+ (LRF homozygous knockout) age: 4 weeks cell type: FACS-sorted LT-HSCs (LSK IL7Ra-Flt3-CD150+CD48-) time point: 9 days after 1st pIpC injection Treatment protocol LT-HSCs were FACS-so
Gene Symbol (human)ZBTB7A
Gene Symbol (mouse)Zbtb7a
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1025390, GSM1025391
Perturbed SamplesGSM1025392, GSM1025393, GSM1025394
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41839
Gene Expression Omnibus
Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs
7
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