Small molecules which reverse SMARCA5 KO
Canned Analysis
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General Information
AccessionDCA00022000
TitleSmall molecules which reverse SMARCA5 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by SMARCA5 KO in the P1 mouse eyeball genotype/variation: Snf2h lens-conditional knockout strain: C57BL/6 age: newborn cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d2263be467bea600fbb216
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2382
Cell TypeP1 mouse eyeball genotype/variation: Snf2h lens-conditional knockout strain: C57BL/6 age: newborn
Gene Symbol (human)SMARCA5
Gene Symbol (mouse)Smarca5
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1020078, GSM1020079, GSM1020080, GSM1020081
Perturbed SamplesGSM1020082, GSM1020083, GSM1020084, GSM1020085
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41608
Gene Expression Omnibus
Chromatin Remodeling Enzyme Smarca5/Snf2h Regulates Cell Cycle Exit, Differentiation of the Lens Epithelium, and Denucleation of Lens Fiber Cells
14
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