Small molecules which reverse SMARCA4 KO
Canned Analysis
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General Information
AccessionDCA00022002
TitleSmall molecules which reverse SMARCA4 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by SMARCA4 KO in the P1 mouse eyeball Brg1 lens-conditional knockout genotype/variation: Brg1_cKO1 strain: mixed background (Gebuhr TC, Kovalev GI, Bultman S, Godfrey V, Su L, Magnuson T. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J Exp Med. 2003 Dec 15;198(12):1937-49.) age: P1 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d218cde467bea600fbac66
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2383
Cell TypeP1 mouse eyeball Brg1 lens-conditional knockout genotype/variation: Brg1_cKO1 strain: mixed background (Gebuhr TC, Kovalev GI, Bultman S, Godfrey V, Su L, Magnuson T. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T
Gene Symbol (human)SMARCA4
Gene Symbol (mouse)Smarca4
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1021209, GSM1021210, GSM1021211
Perturbed SamplesGSM1021212, GSM1021213, GSM1021214
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41608
Gene Expression Omnibus
Chromatin Remodeling Enzyme Smarca5/Snf2h Regulates Cell Cycle Exit, Differentiation of the Lens Epithelium, and Denucleation of Lens Fiber Cells
14
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