Small molecules which mimic DES KO
Canned Analysis
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General Information
AccessionDCA00022007
TitleSmall molecules which mimic DES KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by DES KO in the genetic background: 129/SVE tissue: tibialis anterior age: 7-9 wk treatment: 50 eccentric contractions 12 hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20552e467bea600fba3d0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2387
Cell Typegenetic background: 129/SVE tissue: tibialis anterior age: 7-9 wk treatment: 50 eccentric contractions 12 hours
Gene Symbol (human)DES
Gene Symbol (mouse)Des
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1015522, GSM1015523, GSM1015524, GSM1015525, GSM1015526
Perturbed SamplesGSM1015532, GSM1015533, GSM1015534, GSM1015535, GSM1015536
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41363
Gene Expression Omnibus
Role of the Cytoskeleton in muscle transcriptional response to altered use
14
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