Small molecules which reverse CTLA4 KO
Canned Analysis
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General Information
AccessionDCA00022028
TitleSmall molecules which reverse CTLA4 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by CTLA4 KO in the T cells from 5C.C7 RAG2-/- CD45.1 and 5C.C7 RAG2-/- CD45.1 CTLA-4-/- mice were activated by immunization with MCC peptide and LPS and after 4 days sorted for RNA extraction. cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20ba2e467bea600fba69a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2400
Cell TypeT cells from 5C.C7 RAG2-/- CD45.1 and 5C.C7 RAG2-/- CD45.1 CTLA-4-/- mice were activated by immunization with MCC peptide and LPS and after 4 days sorted for RNA extraction.
Gene Symbol (human)CTLA4
Gene Symbol (mouse)Ctla4
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM921632, GSM921633, GSM921634
Perturbed SamplesGSM921635, GSM921636, GSM921637
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE37563
Gene Expression Omnibus
In vivo gene expression data from wild type and CTLA-4 KO 5C.C7 T cells
7
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