Small molecules which mimic PRMT5 KO
Canned Analysis
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General Information
AccessionDCA00022031
TitleSmall molecules which mimic PRMT5 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by PRMT5 KO in the Neural stem/ progenitor cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20bb1e467bea600fba6a0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorRuta
CREEDS IDgene:2403
Cell TypeNeural stem/ progenitor cells
Gene Symbol (human)PRMT5
Gene Symbol (mouse)Prmt5
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1100469, GSM1100470, GSM1100471, GSM1100472
Perturbed SamplesGSM1100473, GSM1100474, GSM1100475, GSM1100476
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE45269
Gene Expression Omnibus
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery (BeadCh...
7
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