Small molecules which mimic CYP27B1 KO
Canned Analysis
FAIR Metrics
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General Information
AccessionDCA00022033
TitleSmall molecules which mimic CYP27B1 KO
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by CYP27B1 KO in the genotype/variation: Cyp27b1 flox/flox;Cre+ OR Cre- tissue: breast tumor genetic background: FVB cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d20bbae467bea600fba6a4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2404
Cell Typegenotype/variation: Cyp27b1 flox/flox;Cre+ OR Cre- tissue: breast tumor genetic background: FVB
Gene Symbol (human)CYP27B1
Gene Symbol (mouse)Cyp27b1
Organismmouse
Perturbation TypeKO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM992462, GSM992463, GSM992464
Perturbed SamplesGSM992465, GSM992466, GSM992467
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE40375
Gene Expression Omnibus
Lack of local vitamin D synthesis accelerates breast cancer development after Cyp27B1 gene ablation in mammary epithelium
7
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